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Clinical Trial Update: The COMMENCE Study 10-Year Durability Results Released at AATS

Written By: Adam Pick, Patient Advocate, Author & Website Founder
Medical Expert: Lars Svensson, MD, Cleveland Clinic
Published: May 3, 2026

I just learned from Dr. Lars Svensson, Chief of the Heart, Vascular and Thoracic Institute at the Cleveland Clinic, that the 10-year results of the COMMENCE clinical trial just were shared at the American Association for Thoracic Surgery Conference that is happening right now in Chicago, Illinois. The COMMENCE trial is evaluating a new type of heart valve replacement, the INSPIRIS RESILIA, designed for enhanced durability using bovine tissue treated with an integrity preservation technology to resist calcification.

INSPIRIS RESILIA Tissue Valve Studied in COMMENCE Trial

Dr. Svensson shared, "I just had the privilege of presenting the COMMENCE Trial results at AATS. The 10-year data is encouraging, showing low rates of structural valve deterioration and reoperation, even in younger patients who typically face higher risks. This tissue technology could reshape how we think about biological valve durability. Long-term evidence matters."

Presented the COMMENCE Trial at #AATS2026 - the 10 yr data is encouraging, showing low rates of structural valve deterioration & reoperation, even in younger pts who typically face higher risks.
This tissue technology could reshape how we think about biological valve durability. pic.twitter.com/IBBuZrl2Dw
— Lars Svensson (@LarsSvenssonMD) May 2, 2026

Download Dr. Svensson's COMMENCE 10-Year Durability Results Presentation

In addition to the video above, Dr. Svensson also sent me his presentation about the 10-year COMMENCE durability data released at AATS. Click here to download Dr. Svensson's fascinating presentation about the 10-year data results from the COMMENCE clinical trial.

COMMENCE 10-Year Clinical Trial Data Release

Thanks Dr. Svensson!!!

Thanks to Dr. Svensson for letting me know about these late-breaking clinical trial results for the COMMENCE study!

Written by Adam Pick - Patient & Website Founder

Adam Pick is a heart valve patient and author of The Patient's Guide To Heart Valve Surgery. In 2006, Adam founded HeartValveSurgery.com to educate and empower patients. This award-winning website has helped over 10 million people fight heart valve disease. Adam has been featured by the American Heart Association and Medical News Today.

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