Bacterial Endocarditis: What Is It? How Is It Treated?
Written By: Allison DeMajistre, BSN, RN, CCRN
Medical Expert: Laura DiChiacchio, MD, Cardiac Surgeon, Cedars-Sinai, Los Angeles, California
Reviewed By: Adam Pick, Patient Advocate, Author & Website Founder
Published: August 7, 2026
A big concern among patients in our heart valve community is bacterial endocarditis. That’s because the heart is normally protected against infection by a strong immune defense system. But, when someone has a weakened or damaged heart valve, or a mechanical valve, bacteria are more likely to bypass that defense. Understanding more about bacterial endocarditis, its symptoms, and treatment can help heart valve patients better recognize the condition for prompt and effective intervention.
We met with Dr. Laura DiChiacchio, a leading cardiac surgeon at Cedars-Sinai Medical Center in Los Angeles, California, to learn more about bacterial endocarditis and its treatment.
Key Facts Patients Should Know About Bacterial Endocarditis
Here are the important insights shared by Dr. DiChiacchio:
What happens when someone has endocarditis? “Bacterial endocarditis occurs when an infection that has made its way into the bloodstream takes hold of a valve and starts to grow on that valve,” said Dr. DiChiacchio. “When it manifests acutely, it can cause destruction of the valve, and patients will have symptoms related to the valve not functioning well.
According to Dr. DiChiacchio, patients don’t always know an infection is happening and symptoms may be delayed. "They may not be feeling well, or they might be short of breath. Sometimes they have a fever or feel like they can’t keep up with their normal activity. Usually, these symptoms mean that the bacteria are either infecting the valve or starting to destroy it. The body may also be fighting off the bacteria, which can cause scarring and fibrosis making it so the valve can’t function normally," she stated.
How is endocarditis managed? Dr. DiChiacchio said, “The first line therapy is IV antibiotics. Then, we assess how the valve is responding to the infection, how the body is responding to the antibiotics, and whether the antibiotics alone will be enough for treatment. Once the infection really takes hold and there is growth or vegetation on the valve, it usually requires surgery to get the infection out and either repair or replace the valve. If it’s caught early enough, sometimes antibiotics can be enough.”
Thanks Dr. DiChiacchio and Cedars-Sinai Medical Center!
On behalf of all the patients in our community, thank you, Dr. DiChiacchio, for everything you and your team are doing at Cedars-Sinai Medical Center in Los Angeles, California!
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Keep on tickin,
Adam
P.S. For the deaf and hard-of-hearing members of our patient community, we have provided a written transcript of our interview with Dr. DiChiacchio below.
Written by Adam Pick
Patient & Website Founder
Written by Adam Pick - Patient & Website Founder
Adam Pick is a heart valve patient and author of The Patient's Guide To Heart Valve Surgery. In 2006, Adam founded HeartValveSurgery.com to educate and empower patients. This award-winning website has helped over 10 million people fight heart valve disease. Adam has been featured by the American Heart Association and Medical News Today.
Video Transcript:
Adam Pick: Hi everybody. It's Adam with HeartValveSurgery.com, and we're in Los Angeles, California at Cedar-Sinai Medical Center. I'm thrilled to be joined by Dr. Laura DiChiacchio, who is a leading cardiac surgeon. Dr. DiChiachio, it is great to see you again, and thanks so much for being with me today.
Dr. Laura DiChiacchio: Thank you for having me.
Adam Pick: We're here talking about heart valve disease. One of the big questions in our community is about bacterial endocarditis. Can you share what is bacterial endocarditis? How is it managed or treated and what's your advice for patients?
Dr. Laura DiChiacchio: That's a great question. So bacterial endocarditis occurs when an infection that has made its way into the bloodstream actually takes hold of a valve and it starts to grow on that valve.
It can manifest in a couple of ways. Acutely, it can cause destruction of the valve and symptoms related to the valve not functioning well. Sometimes patients don't know that this is occurring and it takes time, and so it'll be a more delayed presentation where they have not been feeling well, they've been short of breath. Maybe they've been having fevers, they're feeling like they can't keep up with their normal activity, and usually it means that that bacteria is either infecting and starting to destroy the valve.
Or the body is fighting off the bacteria and causing scarring and fibrosis of the valve. Either of those things makes it so the valve can't function normally.
Adam Pick: Is this managed by antibiotics? Or by some form of valvular therapy? How do you handle it?
Dr. Laura DiChiacchio: So, the first line therapy is IV antibiotics, then it's an assessment of how the valve is responding to the infection, how the body is responding to the antibiotics. And whether antibiotics alone can be enough. Once the infection really takes hold and there's growth on the valve or a vegetation, if that's a large vegetation, usually it requires surgery to get that out and either repair or replace the valve.
Sometimes if this is caught early, antibiotics can be enough.
Adam Pick: Fantastic. Well, Dr. DiChiacchio, on behalf of the patients in our community, patients all over the world, thanks for everything that you and your team are doing. Thank you. To help patients with bacterial endocarditis and heart valve disease. Thanks for being with me today.
Dr. Laura DiChiacchio: Thank you.
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