About Dr. Mario Castillo-Sang,
Heart Valve Surgeon

Hello! My name is Dr. Mario Castillo-Sang and I am a cardiac surgeon having graduated from Escuela de Medicina Ignacio A Santos in 2004. St. Elizabeth Healthcare performs approximately 600 heart surgeries each year. All St. Elizabeth Healthcare cardiac surgeons complete between 125-150 cardiac cases per year. Read more...

34 Patient Reviews for
Dr. Castillo-Sang

"Absolutely amazing!!!!!!!! Dr. Castillo-Sang has wonderful bedside manners and did an amazing job explaining the procedure."

-- Anna Schroth, Mitral Valve, Valve Replacement, 08/01/2025

"I feel truly blessed to have had my procedure done by Dr. Castillo-Sang and his group of caring professionals.

I am an older patient and he explained the need for the surgery and all the pros and cons. I was never rushed but felt informed and that I had made the right decision. The pre-op procedure was professional and easy to understand. I had the under arm procedure and had a little discomfort but really no significant pain. All the team professionals introduced themselves and were there for me throughout.

Dr. Castillo-Sang visited me and my family several times post-op. The visits were not hurried but gave full information about plans going forward.

I cannot say enough about my high quality of professional care that was always given with kindness. Dr. Castillo-Sang and his team are an asset to the Northern Kentucky medical community."

-- Carolyn Baker, Mitral Valve, Valve Replacement, 07/29/2025

> See 32 more patient testimonials

My Specialities &
Clinical Interests

My heart surgery specialties include:

  • Minimally invasive mitral valve surgery using endoscopic techniques
  • Atrial fibrillation (Maze procedure)
  • Transcatheter valve therapy including TAVR

In addition, I have research and clinical interests specific to:

  • Ventricular contractility in Barlow's mitral valve disease and in bileaflet prolapse
  • Coronary revascularization
  • Mitral valve imaging

Education, Training & Certificates

Dr. Mario Castillo-Sang, heart surgeon, graduated from Escuela de Medicina Ignacio A Santos in 2004.

After medical school, Dr. Castillo-Sang completed a general surgery residency at University of Toledo College of Medicine in 2010. Next, he completed a cardiothoracic surgery fellowship at Washington University Barnes Jewish Hospital in 2012.

Dr. Castillo-Sang is a nationally-recognized heart valve expert that practices in Kentucky. He specializes in minimally-invasive mitral valve repair surgery using endoscopic techniques.

Dr. Castillo-Sang is board certified by the American Board of Thoracic Surgery. Dr. Castillo-Sang has earned a spot on Cincinnati Magazine's "Top Doctors".

Schedule Appointment
with Dr. Mario Castillo-Sang, MD

To schedule an appointment with Dr. Castillo-Sang, you can:

The office of Dr. Castillo-Sang is located at 711 Medical Village Drive, Suite 310, Edgewood, KY 41017. To get driving directions to this office, please click the map below.



> Click for driving directions to Dr. Castillo-Sang’s office.

News & Online References Featuring Dr. Mario Castillo-Sang

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Page last updated: August 28, 2025