About Dr. Mario Castillo-Sang,
Heart Valve Surgeon

Hello! My name is Dr. Mario Castillo-Sang and I am a cardiac surgeon having graduated from Escuela de Medicina Ignacio A Santos in 2004. St. Elizabeth Healthcare performs approximately 600 heart surgeries each year. All St. Elizabeth Healthcare cardiac surgeons complete between 125-150 cardiac cases per year. Read more...

42 Patient Reviews for
Dr. Castillo-Sang

"Very informative doctor. Dr. Castillo-Sang was willing to take the time to make sure I was comfortable with understanding my condition/procedure. Would very highly recommend this doctor to anyone in need."

-- Joel Voet, Mitral Valve, Valve Repair, 11/11/2025

"Dr. Castillo-Sang was very clear from the beginning of the procedure and the steps pre- and post-op. I will be recommending Dr. Castillo-Sang to anyone needing a mitral valve repair."

-- Tyler Dee, Mitral Valve, Valve Repair, 11/11/2025

> See 40 more patient testimonials

My Specialities &
Clinical Interests

My heart surgery specialties include:

  • Minimally invasive mitral valve surgery using endoscopic techniques
  • Atrial fibrillation (Maze procedure)
  • Transcatheter valve therapy including TAVR

In addition, I have research and clinical interests specific to:

  • Ventricular contractility in Barlow's mitral valve disease and in bileaflet prolapse
  • Coronary revascularization
  • Mitral valve imaging

Education, Training & Certificates

Dr. Mario Castillo-Sang, heart surgeon, graduated from Escuela de Medicina Ignacio A Santos in 2004.

After medical school, Dr. Castillo-Sang completed a general surgery residency at University of Toledo College of Medicine in 2010. Next, he completed a cardiothoracic surgery fellowship at Washington University Barnes Jewish Hospital in 2012.

Dr. Castillo-Sang is a nationally-recognized heart valve expert that practices in Kentucky. He specializes in minimally-invasive mitral valve repair surgery using endoscopic techniques.

Dr. Castillo-Sang is board certified by the American Board of Thoracic Surgery. Dr. Castillo-Sang has earned a spot on Cincinnati Magazine's "Top Doctors".

Schedule Appointment
with Dr. Mario Castillo-Sang, MD

To schedule an appointment with Dr. Castillo-Sang, you can:

The office of Dr. Castillo-Sang is located at 711 Medical Village Drive, Suite 310, Edgewood, KY 41017. To get driving directions to this office, please click the map below.



> Click for driving directions to Dr. Castillo-Sang’s office.

Watch Educational Video with Dr. Mario Castillo-Sang

Learn about heart valve surgery from Dr. Castillo-Sang in this video:

  • Endoscopic Cardiac Surgeons Club: What Should Patients Know?

Page last updated: November 19, 2025