About Dr. Mario Castillo-Sang,
Heart Valve Surgeon

Hello! My name is Dr. Mario Castillo-Sang and I am a cardiac surgeon having graduated from Escuela de Medicina Ignacio A Santos in 2004. St. Elizabeth Healthcare performs approximately 600 heart surgeries each year. All St. Elizabeth Healthcare cardiac surgeons complete between 125-150 cardiac cases per year. Read more...

26 Patient Reviews for
Dr. Castillo-Sang

"I would definitely recommend Dr. Castillo-Sang. He is personable, answers any questions you may have, and explains the procedures carefully. You are in good hands with him and his team. His staff is also good to work with. Of course, I was his favorite patient."

-- Patricia Wasson, Mitral Valve, Valve Repair, 05/13/2025

"Dr. Castillo-Sang was great throughout the whole process. He thoroughly explained the procedure and the options going into surgery. He was there post-op to continuously monitor my status and that I was getting whatever I needed.

He always took the time to explain and/or answer all of our questions in the hospital and at the post-op appointment.

I am feeling great and I am up and getting around and it’s been less than two weeks. So, I am very excited with the results."

-- Mary McCann, Mitral Valve, Valve Replacement, 05/05/2025

> See 24 more patient testimonials

My Specialities &
Clinical Interests

My heart surgery specialties include:

  • Minimally invasive mitral valve surgery using endoscopic techniques
  • Atrial fibrillation (Maze procedure)
  • Transcatheter valve therapy including TAVR

In addition, I have research and clinical interests specific to:

  • Ventricular contractility in Barlow's mitral valve disease and in bileaflet prolapse
  • Coronary revascularization
  • Mitral valve imaging

Education, Training & Certificates

Dr. Mario Castillo-Sang, heart surgeon, graduated from Escuela de Medicina Ignacio A Santos in 2004.

After medical school, Dr. Castillo-Sang completed a general surgery residency at University of Toledo College of Medicine in 2010. Next, he completed a cardiothoracic surgery fellowship at Washington University Barnes Jewish Hospital in 2012.

Dr. Castillo-Sang is a nationally-recognized heart valve expert that practices in Kentucky. He specializes in minimally-invasive mitral valve repair surgery using endoscopic techniques.

Dr. Castillo-Sang is board certified by the American Board of Thoracic Surgery. Dr. Castillo-Sang has earned a spot on Cincinnati Magazine's "Top Doctors".

Schedule Appointment
with Dr. Mario Castillo-Sang, MD

To schedule an appointment with Dr. Castillo-Sang, you can:

The office of Dr. Castillo-Sang is located at 711 Medical Village Drive, Suite 310, Edgewood, KY 41017. To get driving directions to this office, please click the map below.



> Click for driving directions to Dr. Castillo-Sang’s office.

News & Online References Featuring Dr. Mario Castillo-Sang

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Page last updated: May 22, 2025