{"id":5618,"date":"2025-05-12T04:40:00","date_gmt":"2025-05-12T04:40:00","guid":{"rendered":"https:\/\/www.heart-valve-surgery.com\/learning\/?page_id=5618"},"modified":"2025-07-22T17:01:17","modified_gmt":"2025-07-22T17:01:17","slug":"savr-tavr-survival","status":"publish","type":"page","link":"https:\/\/www.heart-valve-surgery.com\/learning\/savr-tavr-survival\/","title":{"rendered":"SAVR vs. TAVR Survival: Patients Over 65 Years Old"},"content":{"rendered":"<p>The field of heart valve replacement is an incredibly fast-moving space. It\u2019s only been a little over a decade since the FDA approved transcatheter aortic valve replacement (TAVR) for high-risk surgical patients. Now, with its approval for intermediate and low-risk patients, there are over one million TAVR patients worldwide.<\/p>\n<p>However, many surgeons continue to recommend surgical valve replacement (SAVR) for intermediate and low-risk patients despite TAVR\u2019s attractive benefits including no incision to the patient\u2019s chest, shorter hospital stays and faster recovery. Surgeons are continually studying data comparing TAVR and SAVR to determine how each can address two of their most significant concerns: patient safety and long-term outcomes.<\/p>\n<p>We received a patient question focusing on this important topic from Mossimo, who asked, \u201cI found an interesting <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38867365\/\">European study about outcomes of TAVR versus SAVR<\/a> conducted on a group of over 19,000 people aged 65 or older. What this study is revealing is that in patients 65 years and older with severe aortic stenosis, selection for SAVR is associated with improved long-term survival compared with TAVR. Thoughts?\u201d<\/p>\n<p>We were able to get an answer for Mossimo from <a href=\"https:\/\/www.heart-valve-surgery.com\/surgeons\/dr-Marc-Gerdisch-Indianapolis-Indiana.php\">Dr. Marc Gerdisch<\/a> during the Society of Thoracic Surgeons Conference in Los Angeles, California. Dr. Gerdisch is the Chief of Cardiac Surgery at Franciscan Health in Indianapolis. During his incredible career, he has performed over 4,000 heart valve procedures, and we were thrilled to hear his thoughts about TAVR versus SAVR research.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/TjsX7yd20GM?rel=0?si=JASDnxPDFz-RfA1U\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><span data-mce-type=\"bookmark\" style=\"display: inline-block; width: 0px; overflow: hidden; line-height: 0;\" class=\"mce_SELRES_start\">\ufeff<\/span><span data-mce-type=\"bookmark\" style=\"display: inline-block; width: 0px; overflow: hidden; line-height: 0;\" class=\"mce_SELRES_start\">\ufeff<\/span><span data-mce-type=\"bookmark\" style=\"display: inline-block; width: 0px; overflow: hidden; line-height: 0;\" class=\"mce_SELRES_start\">\ufeff<\/span><span data-mce-type=\"bookmark\" style=\"display: inline-block; width: 0px; overflow: hidden; line-height: 0;\" class=\"mce_SELRES_start\">\ufeff<\/span><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<h2>SAVR Versus TAVR in Patients Over 65 Years Old<\/h2>\n<p>Here are the key highlights shared by Dr. Gerdisch:<\/p>\n<ul>\n<li>Understanding TAVR and its consequences over time. \u201cThis is really fascinating,\u201d said Dr. Gerdisch. \u201cWhat we\u2019ve been seeing is kind of a pendulum swing. I\u2019m going to take the clock back about two years when we started seeing signals that transcatheter valves wouldn\u2019t work out well for younger folks. There was this kind of fever that went across the entire nation with people under 65 receiving transcatheter valves. It came at such a pace that we started to recognize that we were suffering some ill consequences from that over time.\u201d Dr. Gerdisch explained that they now understand the need to strategize for lifetime management while understanding more about the durability of transcatheter valves. \u201cWe have some ideas, but we don\u2019t fully understand it. We know in younger people that tissue valves wear out faster and don\u2019t last as long.\u201d<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Why do some patients over 65 do better with SAVR? \u201cTranscatheter valves have been revolutionary,\u201d said Dr. Gerdisch. \u201cThey have changed the trajectory of life for so many people and are a marvelous technology.\u201d However, he explained that some patients over 65, particularly in some healthier subgroups with a physiology that gives them the opportunity to live a long time, may do better with a surgical valve. \u201cWhen we put a transcatheter valve in, we challenge the native leaflets. Especially with aortic stenosis, where there is calcification in the leaflets. The bulkier the calcification, the worse the stenosis over time. This also means that bulky calcification out into the sinuses causes little bulges at the first part of the aorta. So, now you have this cylinder of a transcatheter valve with lumps of calcium surrounding it, which create \u201cneo-sinuses,\u201d or new sinuses created from the calcium masses inside those sinuses.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5682 aligncenter\" src=\"https:\/\/www.heart-valve-surgery.com\/learning\/..\/Images\/neo-sinus-tavr.jpg\" alt=\"Neo Sinus TAVR\" width=\"650\" height=\"365\" \/><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Transcatheter valves continue to change in shape and size. \u201cPeople thought that if you just move those calcium masses over, they will simply sit there, but it doesn\u2019t do that. Instead, as people age with their transcatheter valves, the calcium masses change in shape and size, changing the flow dynamic of the aortic root and reorganizing the way the blood flow moves in the aortic root. So, what we thought might be a static situation is not. Anyone who has some longevity will see a continued change in the behavior of the tissue around the valve. That\u2019s one of the things we see in the studies looking at explanted transcatheter valves in someone who died. We get to look at those valves, and the most recent paper out of Vancouver that looked at the calcification around the valve showed us that it changed.\u201d<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Valve deployment is not perfect and contributes to potential complications. Dr. Gerdisch said, \u201cThe other thing that is revealed every time we look at large numbers of transcatheter valves is that they are not perfectly deployed. If they got perfectly deployed, you\u2019d have a perfect circle; all leaflets work how you want them to. But most of the time, that\u2019s not what the root architecture allows. So, you have one leaflet that doesn\u2019t move quite as well, with the potential of forming a thrombus and diminishing the valve&#8217;s longevity. In my mind, this shows the difference between the surgical valve, where we cut everything out and sew the valve so that it stays that way until it deteriorates inside a tissue valve. In a transcatheter valve, we implant it, and we may think it looks good, but we don\u2019t have the granular information.\u201d<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Common findings when comparing transcatheter versus surgical valves immediately after treatment. Dr. Gerdisch explained that without getting into the absolute numbers that confounding factors can\u2019t account for, studies do show a common factor when comparing transcatheter to surgical valves. \u201cEvery time we look, we see two things. Immediately at the time of the procedure, the advantage goes to transcatheter valves with respect to complications, which makes sense. You come in, do your valve, and go home the same day. The only complication that we see more in transcatheter than surgical valves is pacemakers. In places that do a lot of SAVRs, the is probably two and a half or three percent and nationally it might be four and a half percent, but with transcatheter valves that rate would never get that low. But the other complications are about equal including the incidence of stroke and mortality depending on the subpopulation of patients.\u201d<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>The comparisons change over time. \u201cWhen you get out to about three years, we consistently see that the lines start to get close on mortality. Once you get out to five years, you start to see a distinct difference. There is some recent data published at ten years and it\u2019s pretty stark with a big difference in survival.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<ul>\n<li>Patients over 65 could need their replacement valve for quite some time. \u201cThe average 63-year-old in the United States has a further lifespan of 20 years. Some 65-year-olds will live another 30 or 35 years. So, if we have a 65 or 70-year-old that is robust, there is a good chance we are going to be dealing with that valve for quite a long time.\u201d Dr. Gerdisch explained that this further longevity is why the data shows that survivability with SAVR becomes better over time than with TAVR. \u201cTissue valves are not static. As soon as a tissue valve goes in, they are subject to your immune system and the milieu that they are in. They are all going to start to deteriorate and if those leaflets aren\u2019t perfectly expanded, if there\u2019s any pinwheeling of the valve like is seen with TAVR, then we will see some accelerated deterioration and I think we start paying that price. We get three, four, or five years out and that\u2019s why we see this data showing up now. We needed the time after putting those valves into people legitimately and appropriately and then make those comparisons.\u201d<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>Thanks Dr. Gerdisch and Franciscan Health!<\/h2>\n<p>On behalf of all the patients in our community, thank you <a href=\"https:\/\/www.heart-valve-surgery.com\/surgeons\/dr-Marc-Gerdisch-Indianapolis-Indiana.php\">Dr. Marc Gerdisch<\/a>, for everything you and your team are doing at Franciscan Health!<\/p>\n<p>Related Links:<\/p>\n<ul>\n<li><a href=\"https:\/\/www.heart-valve-surgery.com\/learning\/calcification-stroke-risk-gerdisch\/\">Stroke Risk &amp; Heart Valve Calcification: What Should You Know?<\/a><\/li>\n<li><a href=\"https:\/\/www.heart-valve-surgery.com\/learning\/new-diagnosis-top-facts\/\">See the Top 5 Facts for Newly Diagnosed Patients<\/a><\/li>\n<li><a href=\"https:\/\/www.heart-valve-surgery.com\/videos\/ask-dr-marc-gerdisch-2025\">Watch the Patient Webinar, \u201cAsk Dr. Gerdisch Anything\u201d<\/a><\/li>\n<\/ul>\n<p>Keep on tickin,<br \/>\nAdam<\/p>\n<p>P.S. For the deaf and hard-of-hearing members of our patient community, we have provided a written transcript of our interview with Dr. Gerdisch below.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"cms.php","meta":{"_acf_changed":false,"footnotes":""},"categories":[6],"class_list":["post-5618","page","type-page","status-publish","hentry","category-aortic-valve-replacement"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/pages\/5618","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/comments?post=5618"}],"version-history":[{"count":16,"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/pages\/5618\/revisions"}],"predecessor-version":[{"id":5969,"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/pages\/5618\/revisions\/5969"}],"wp:attachment":[{"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/media?parent=5618"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/categories?post=5618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}