{"id":1495,"date":"2021-09-28T22:04:44","date_gmt":"2021-09-28T22:04:44","guid":{"rendered":"https:\/\/www.heart-valve-surgery.com\/learning\/?page_id=1495"},"modified":"2025-05-29T22:14:04","modified_gmt":"2025-05-29T22:14:04","slug":"bicuspid-4d-flow-mri-aorta-dilation","status":"publish","type":"page","link":"https:\/\/www.heart-valve-surgery.com\/learning\/bicuspid-4d-flow-mri-aorta-dilation\/","title":{"rendered":"Breaking Research: 4D Flow MRI Predicts Aneurysm Risk in Bicuspid Aortic Valve Patients"},"content":{"rendered":"<p><a href=\"https:\/\/www.heart-valve-surgery.com\/bicuspid-aortic-valve-symptoms.php\">Bicuspid aortic valve disease<\/a> is one of the most common forms of congenital heart disease impacting between 1% to 2% of the population.\u00a0 Interestingly, some patients with bicuspid aortic valves develop aortic aneurysms, a swelling (or bulging) of the aorta than can lead to life-threatening situations.\u00a0 Other bicuspid aortic valve patients, however, never develop an aneurysm.<\/p>\n<p>For that reason, many patients and physicians have wondered, &#8220;Is it possible to create a diagnostic test for bicuspid aortic valve patients that can predict whether-or-not a patient is at risk for an aortic aneurysm?&#8221;<\/p>\n<p>Here&#8217;s the wonderful news&#8230; I am thrilled to share that a diagnostic test for predicting aorta dilation in bicuspid aortic valve patients now exists!!!<\/p>\n<p>Thanks to innovative research from the <a href=\"https:\/\/www.nm.org\/conditions-and-care-areas\/cardiovascular-care\/center-for-heart-valve-disease\/bicuspid-aortic-valve\/specialists-and-care-centers\">Bicuspid Aortic Valve Program at Northwestern Medicine<\/a>, a team of scientists, surgeons, researchers, cardiologists and imaging specialists are <span class=\"style-scope yt-formatted-string\" dir=\"auto\">using 4D Flow MRI technology to identify a new &#8220;biomarker&#8221; to predict aorta dilation in bicuspid aortic valve patients.\u00a0 In this video, we interview <a href=\"https:\/\/www.feinberg.northwestern.edu\/faculty-profiles\/az\/profile.html?xid=21060\">Dr. Michael Markl<\/a>, Vice Chair and Professor of Research at Northwestern Medicine, to learn how 4D Flow MRI technology can help doctors better manage the potential risk of aortic aneurysms in bicuspid aortic valve patients.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/53awEQ23COM?rel=0\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<h2>Key Insights About 4D Flow MRI &amp; Aorta Dilation for Patients<\/h2>\n<p>Dr. Markl shared several important points during this interview that I want to highlight for our patient community:<\/p>\n<ul>\n<li>In his role at the <a href=\"https:\/\/www.nm.org\/conditions-and-care-areas\/cardiovascular-care\">Bluhm Cardiovascular Institute<\/a> at Northwestern Medicine, Dr. Markl leads a multi-disciplinary team that develops new imaging technologies to help physicians better manage and treat heart disease and stroke.<\/li>\n<li>4D Flow MRI is a novel imaging technology developed at Northwestern Medicine. With 4D Flow MRI, physicians can measure blood flow through the heart and the aorta of patients.<\/li>\n<li>Bicuspid aortic valves are malformed, two-cusp valves that can lead to serious symptoms (shortness of breath, fatigue, chest pain, dizziness) and complications (aortic aneurysms, heart failure and death) for patients.\u00a0 A normal aortic valve has three cusps.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full aligncenter\" src=\"https:\/\/www.heart-valve-surgery.com\/Images\/bicuspid-aortic-valve-comparison.jpg\" alt=\"Normal and Bicuspid Aortic Valve\" width=\"600\" height=\"269\" \/><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Historically, cardiologists and cardiac surgeons have been puzzled by the development of <a href=\"https:\/\/www.heart-valve-surgery.com\/aortic-aneurysm.php\">aortic aneurysms<\/a> in patients with bicuspid aortic valves. Dr. Markl states, &#8220;One of the questions that always puzzled cardiologists and cardiac surgeons is, &#8216;Why is it that one group of BAV patients develops complications while another group of BAV patients do not have complications?&#8217; This new study addresses this important question.&#8221;<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full aligncenter\" src=\"https:\/\/www.heart-valve-surgery.com\/Images\/aortic-root-aneurysm.gif\" alt=\"Aortic Aneurysm &amp; Aortic Valve\" width=\"300\" height=\"318\" \/><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>In <a href=\"https:\/\/www.heart-valve-surgery.com\/JACC-Cardiovascular-Imaging-Bicuspid-Aortic-Valve-Aorta-Dilation-4D-Flow-MRI.pdf\">this longitudinal study<\/a>, the Northwestern Medicine team found that 4D Flow MRI can help identify a unique biomarker known as &#8220;wall shear stress&#8221;.\u00a0 This biomarker can predict the potential development of aortic dilation in a patient. Dr. Markl states, &#8220;It turns out if you have more wall shear stress in your aorta, you&#8217;re at higher risk for aortic dilation. This may eventually lead to the need for surgery and valve repair in those patients.&#8221;<\/li>\n<li>Wall shear stress measures the drag force of blood on the aortic wall. That force can ultimately cause disease and aortic complications.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1589 aligncenter\" src=\"https:\/\/www.heart-valve-surgery.com\/learning\/..\/Images\/wall-shear-stress-4d-mri-flow.jpg\" alt=\"4D Flow MRI - Bicuspid Aortic Valve Wall Shear Stress\" width=\"700\" height=\"390\" \/><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>The uniqueness of this study is that Northwestern Medicine was able to measure wall shear stress &#8220;in vivo&#8221;, in patients, using 4D Flow MRI.<\/li>\n<li>The application of 4D Flow MRI and the wall shear stress biomarker is very helpful for heart teams to manage patients with a bicuspid aortic valve.\u00a0 Dr. Markl states, &#8220;It really is a tool to hopefully better manage patients and plan ahead for the remainder of their lives. Bicuspid aortic valve is a birth defect. It&#8217;s something you carry with in your life.\u00a0 You really want to plan ahead and manage that care as efficiently as possible for the patient.&#8221;<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2>Congratulations to Dr. Markl &amp; Northwestern Medicine!!!<\/h2>\n<p>On behalf of the patients at HeartValveSurgery.com &#8211; especially the bicuspid aortic valve patients &#8211; I\u2019d like to extend a big-time \u201cCongratulations!!!\u201d to Dr. Markl and his entire team at <a href=\"https:\/\/www.heart-valve-surgery.com\/hospital\/northwestern-memorial-valve-program\">Northwestern Medicine<\/a> for this exciting and very encouraging research!\u00a0 I imagine this new application of 4D Flow MRI and wall shear stress will help many, many, many patients in the future!<\/p>\n<p>Keep on tickin!<br \/>\nAdam<\/p>\n<p>P.S. I have provided a written transcript of this video interview below.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"cms.php","meta":{"_acf_changed":false,"footnotes":""},"categories":[11],"class_list":["post-1495","page","type-page","status-publish","hentry","category-medical-technology"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/pages\/1495","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/comments?post=1495"}],"version-history":[{"count":24,"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/pages\/1495\/revisions"}],"predecessor-version":[{"id":5837,"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/pages\/1495\/revisions\/5837"}],"wp:attachment":[{"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/media?parent=1495"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.heart-valve-surgery.com\/learning\/wp-json\/wp\/v2\/categories?post=1495"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}