{"id":3822,"date":"2011-02-15T14:43:56","date_gmt":"2011-02-15T19:43:56","guid":{"rendered":"http:\/\/www.heart-valve-surgery.com\/heart-surgery-blog\/?p=3822"},"modified":"2019-03-01T22:41:09","modified_gmt":"2019-03-02T03:41:09","slug":"extracellular-matrix-marc-gerdisch-video","status":"publish","type":"post","link":"https:\/\/www.heart-valve-surgery.com\/heart-surgery-blog\/2011\/02\/15\/extracellular-matrix-marc-gerdisch-video\/","title":{"rendered":"Technology Update: &#8220;Will Extracellular Matrix Help Patients Grow Their Own Heart Valves?&#8221; By Dr. Marc Gerdisch"},"content":{"rendered":"<p>Advances in medical technology for valvular treatment continue to evolve rapidly. Recently,\u00a0I learned more about the use of Extracelluar Matrix (ECM) for heart valve repair and remodeling from <a href=\"https:\/\/www.heart-valve-surgery.com\/surgeons\/dr-Marc-Gerdisch-Indianapolis-Indiana.php\">Dr. Marc Gerdisch<\/a>, the chief of cardiothoracic surgery at St. Francis Heart Center in Indianapolis, Indiana. In 2008, Doctor Gerdisch was the world&#8217;s first surgeon to use ECM to repair a damaged heart valve.<\/p>\n<p>Here is my interview with Dr. Gerdisch. This discussion was in direct response to Scott&#8217;s question, &#8220;Will patients be able to grow their own heart valves in the future?&#8221;<\/p>\n<p>&nbsp; <\/p>\n<p style=\"text-align: center;\"><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/gslNU29ULQs\" frameborder=\"0\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp; <\/p>\n<p style=\"text-align: left;\">To help you learn more about Extracellular Matrix and Dr. Gerdisch, I have provided an additional video about ECM and a transcript of this interview below.<\/p>\n<p><!--more--><\/p>\n<p>Adam:\u00a0 Hey, everybody.\u00a0 This is Adam and again we\u2019re here at STS in San Diego for the 47th annual event. I\u2019m thrilled to be with Dr. Marc Gerdisch from St. Francis Heart Center in Indianapolis. As you know, we\u2019re answering your heart valve repair and heart valve replacement questions that you put up on HeartValveBlog.com. We have a great question from Scott and it\u2019s all about technology and how technology\u2019s impacting heart valves and heart valve surgery. Scott writes, &#8220;I\u2019ve heard about a new technology in which doctors can grow their own heart valves.\u00a0 What is the latest on this research?&#8221;<\/p>\n<p>Dr. Gerdisch:\u00a0 Absolutely.\u00a0 This is really, really exciting stuff right now because we actually are on that path. I guess there\u2019s different ways to look at it as far as how far we are on it.\u00a0 We think we\u2019ve actually made a fair amount of progress and, in fact, in humans we have done some work where we\u2019ve reconstructed portions of heart valves and portions of adjacent heart tissue using what\u2019s called <a href=\"http:\/\/www.cardiactissuerepair.net\">Extracelluar Matrix<\/a>.\u00a0 This is basically tissue without the cells, completely decellularized, but with the framework in which cells live and that replacement is actually dynamic.\u00a0 In other words, it\u2019s not something you put in that\u2019s a static patch that stays the same forever.\u00a0 What happens is your cells are integrated into it.\u00a0 It becomes repopulated with cells, with new cells, and as a function of those cells being there, being present in the matrix, the cells actually do their job and will replace the matrix over time.\u00a0 So what you have implanted that eventually is replaced by the activity of your own cell.\u00a0 As you know, any cell in your body can be any cell in your body so the same cell in your eyeball can be the cell in your big toe.\u00a0 They all have the same genetic information.\u00a0 So we have this.\u00a0 It becomes repopulated.\u00a0 It\u2019s your tissue and it\u2019s not a foreign body so the impact of that is, over time, our expectation is that this is going to outlast previous devices and it will provide patients\u00a0 something that they won\u2019t identify as foreign and won&#8217;t induce inflammation. So that\u2019s what we\u2019ve done so far.\u00a0 Now on a more \u2014 as far as a trajectory toward building an entire valve, we have started to do some work in animals and it\u2019s been very, very promising and it \u2014 so much so that I feel like we\u2019ve got the platform now that\u2019s going to launch us on to that technology.\u00a0 It\u2019s not something that\u2019s going to happen overnight.\u00a0 These are huge steps.\u00a0 We\u2019re taking small steps toward it but we\u2019ve made some real solid progress with it.\u00a0 Some of the things I can\u2019t actually describe to you, I can\u2019t tell you about, because they\u2019re unique and they\u2019re not ready for prime time, but I can tell you that we have made a fair amount of progress because we\u2019ve got that platform down and we\u2019re working hard to get to the point where we can go about it.<\/p>\n<p>Adam:\u00a0 Got it.\u00a0 So, I have a followup question and I have a statement.\u00a0 We\u2019ll start with the question.\u00a0 Not to put you on the spot, but do you have any kind of estimate in where there might be something tangible in which the technology actually can regenerate a valve, a part of valve?\u00a0 Is it possible or is that just not \u2014 not yet?<\/p>\n<p>Dr. Gerdisch:\u00a0 No.\u00a0 Definitely a part of valve.\u00a0 We\u2019ve done that.\u00a0 I\u2019ve got roughly 60 patients that I\u2019ve reconstructed some portion of the interior of the heart. Many times it\u2019s the valve.\u00a0 Many times it\u2019s part of the valve.\u00a0 Lately, other surgeons have been doing that.\u00a0 Surgeons who are very well know for reconstructive techniques in valve surgery are now adopting that with Extracelluar Matrix, so the use of the matrix means that the patient\u2019s own cells are going to populate that portion of the tissue and they\u2019re not going to have that foreign body.\u00a0 So we\u2019ve done that.\u00a0 Parts of valves have been repaired using this technology.\u00a0 The next step is to build a valve and, like I said, we\u2019re kind of in the early phases of it.\u00a0 Things are moving very quickly.\u00a0 Now that doesn\u2019t mean that next year there\u2019s going to be some \u2014 or even in two years, but compared to other technology of this nature, we\u2019re making progress a lot faster than we expected and I don\u2019t think it\u2019s unreasonable to expect that in my career, anyway, we\u2019re going to be able to replace a valve with a clone, a valve that grows, a valve that develops.<\/p>\n<p>Adam:\u00a0 Amazing.<\/p>\n<p>To learn more, please see Dr. Marc Gerdisch&#8217;s surgeon profile or call (877) 78-VALVE (82583).<\/p>\n<p>Keep on tickin!<br \/>\nAdam<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":22351,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[68],"tags":[],"class_list":["post-3822","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medical-technology"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.heart-valve-surgery.com\/heart-surgery-blog\/wp-json\/wp\/v2\/posts\/3822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.heart-valve-surgery.com\/heart-surgery-blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.heart-valve-surgery.com\/heart-surgery-blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.heart-valve-surgery.com\/heart-surgery-blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.heart-valve-surgery.com\/heart-surgery-blog\/wp-json\/wp\/v2\/comments?post=3822"}],"version-history":[{"count":0,"href":"https:\/\/www.heart-valve-surgery.com\/heart-surgery-blog\/wp-json\/wp\/v2\/posts\/3822\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.heart-valve-surgery.com\/heart-surgery-blog\/wp-json\/wp\/v2\/media\/22351"}],"wp:attachment":[{"href":"https:\/\/www.heart-valve-surgery.com\/heart-surgery-blog\/wp-json\/wp\/v2\/media?parent=3822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.heart-valve-surgery.com\/heart-surgery-blog\/wp-json\/wp\/v2\/categories?post=3822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.heart-valve-surgery.com\/heart-surgery-blog\/wp-json\/wp\/v2\/tags?post=3822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}