What Are The Common Coumadin Medication Interactions?

As we’ve talked about before, Coumadin (Warfarin Sodium) is used by patients following heart valve replacement in which mechanical heart valves are selected by the patient and/ or surgeon. You can click here to learn more about Coumadin medication and its long-term use for preventing blood clots on mechanical heart valves following heart valve surgery.

Coumadin Medication Interactions

That said, this blog is also starting to answer some questions about Coumadin medication interactions with other popular drugs – including Coumadin and Prilosec and Ultram and Coumadin.

In the near future, Dr. Robert Light and I are going to be addressing some of the other contraindications of Coumadin use and pharmaceuticals.

However, I did want to briefly identify some of the more well-known Coumadin medication interactions such that we have a baseline of the other research we are about to conduct. With that said, I spent some time researching coumadin medication interactions.

Here is a quick list of the common Coumadin medication interactions I located:

  • Amiodarone
  • Cimetadine
  • Clofibrate
  • Cotrimoxazole
  • Erythromycin
  • Fluconazole
  • Isoniazid
  • Metronidazole
  • Miconazole
  • Omeprazole
  • Phenylbutazone
  • Piroxicam
  • Propafenone
  • Propanolol
  • Sulfinpyrazone
  • Acetaminophen (Tylenol┬«)
  • Anabolic steroids
  • Aspirin
  • Chloral Hydrate
  • Ciprofloxacin
  • Dextropropoxyphene
  • Disulriam
  • Quinidine
  • Phenytoin (Dilantin┬«)
  • Simvastatin
  • Tamoxifen
  • Tetracycline
  • Influenza vaccine

I hope this helps explain some of the Coumadin medication interactions. In future blogs, Dr. Robert Light and I are going to further explore this topic.

Keep on tickin!

Adam Pick
Written by Adam Pick

Adam Pick is a patient, author of The Patient's Guide To Heart Valve Surgery and the founder of HeartValveSurgery.com.

To learn how Adam has helped millions of people with heart valve disease, watch Adam's video, subscribe to his free newsletter, or visit his Facebook, or Twitter pages.

  • Maureen Sadang

    I am scheduled for surgery to replace the aortic valve. I can’t decide which kind of valve to choose. the warfarin treatment seems so cumbersome and risky. Do warfarin users find it workable or is it better to go with the tissue valve and pray that research comes up with some better answers before the valve wears out? thanks for any input, Maureen- I am taking simvastatin which according to your list is not compatible with warfarin. I also use Tylenol. what are the alternatives? thanks again

  • Anne Cahill

    This is in reply to Maureen. I had arotic value surgery 21 years ago this past June 2nd. I have a mechanical value. I was 43 at the time of my surgery. I am on coumadin and I do take Lipitor. Recently, I started taking simvastatin instead of Lipitor for about 4 months. I did not like being on simvastatin so I switched back to Lipitor. Yes, the coumadin blood tests are a pain, but for me at the time it seemed the only way to go because I really didn’t want to face another heart surgery in my life time. However, that said if I had been much older, I think at this time I would have taken my chances and gone with the tissue valve. Goodluck, and know that once the surgery is over you are going to feel so much better after your recovery process. Remember to think positive! It will help so much in your recovery.

  • Frank Brady

    Is there a natural substitute for coumadin? Does coumadin interact negatively with metformin, simvastatin, lisonpril, atenolol?

  • fazilat

    hi I am on warfarin takes a little time to get into the routine then it becomes second nature. i was 42 when i had the op aortic valve replacement and i had no choice it was mechanical only. i eat all types of food, medication i check with the doc and blood testing time is getting longer i.e from 3 days now to monthly. good luck with whatever you decide.

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